Levitra Ե



4 ͧ 1 ͧ


Ե 20mg. (Levitra 20mg.) BAYER. ѹ



ǹСͺ ::

Ե 20 :: 1 Сͺ Vardenafil 20mg.

ǹСͺ ::

Crospovidone, magnesium stearate,

microcrystalline

Cellulose, colloidal silicon dioxide (silica colloidal

Anhydrous), polyethylene glycol (macrogal 400),

Hypromellose (hydroxyl-methylcellulose), titanium

Dioxide (E717), ferric oxide yellow (E172), ferric

Oxide red (E172)

سѵ

秵ǢͧȪ繢ǹ¹ŧ

ͧ¹

ͧԵ鹡ѺäµǢͧº

corpus cavernosum

ǢͧѺʹᴧ ҧա

е鹷ҧա

乵ԡ͡䫴͡ҡ»ҷͧ

corpus cavernosum

仡е͹䫴 guanylate cylase ռ

дѺ cyclic

guanosine monophoshate (cGMP) corpus

cavernosum

ԴäµǢͧºռŷʹ

价ҡ

Vardenafil Ѻ͹䫴 PDE5 ͹䫴

ռŷ cGMP

͡ corpus cavernosum vardenafil ֧

ķռŵ

Nitric oxide ١Ŵ¨ҡ corpus cavernosum

ѹշѺ

е鹷ҧ

ѧ Ե ֧ԡҵͺʹͧҧҵ

͡áе鹷ҧ

ͺ

ѡä͹öҾҧ㹼 (

秵ҹ

ͷѹ쨹繷֧)



㹼·ǵǹСͺ (駵Ӥѭе

ǹСͺ)

ҡŢͧѺ PDE ͢ǹ nitric oxide /

cGMP ҡѺ

͹䫴 PDF5 Ҩռķ㹡Ŵ

ѹԵͧ nitrae

ѧ鹨֧ Ե Ѻ nitrae ҷ

nitric oxide.

·ѡä͹öҾҧ

㹼·й

Ԩҧ ( ·դԴԷҧк

ʹʹҧ

عç ·ҡûǴ

عç (Ҥ

ᾷä III IV)

Ե ѺѺ͹䫴 cytochrome

P450 3A4 դ

ç (ritonavir, indinavir,ketoconazole

itraconazole (ԴѺзҹ)

㹼ª·ҡ 75

ҡ֧ʧ

ա Ե 㹼ҡ 3,750

çԨ·š

»Լ· Ե .

ҡ֧ʧ »Ԩ繪ǤдѺ

عç¶֧ҹҧ

ҴԸѺзҹ (ҴһԷй)

Ҵ鹷йӤ 10 . ҳ 25 ҷ ֧

1 . ͹աԨҧ

ͧҴҷй٧ش ö

Ե ѹ 1 Ѻзҹ

Ե ҷͧҧ Ѻзҹ

ѧͧ áе

ҧ͡õͺʹͧҧҵԡѡ

ǹͧҴ ::

ѺԷԼС÷ ҴҨ

鹶֧ 20 . Ŵŧ 5 .

Ҵ٧شйӤ 20 . ѹФ Ҵ٧

شԹ 5 .

Ѻ erythromycin Ѻ CYP3A4 Ф

ա§Ѻ

Ѻ cytocrome P 450 (CYP) 3A4 դç

ketoconazole,

Itraconazole, indinavir ritonavir

Ըա (¡Ѻзҹ)

٧ (ҡ 65 )

ͧҡâѴ vardenafil 㹼٧Ŵŧ

Ǵ¢Ҵ 5 .

Ҩ 10 20 . Ѻ÷

лԷԼ

Фصӡ 18

й Ե 㹤صӡ 18 .

·դԴԷѺ

鹴¢Ҵ 5 . .㹼·դԴ

Ѻ͹ ҹҧ

(Child-Pugh A-B) ҴҨ 10 . Ш

֧ 20 .

Ѻ÷лԷԼ

·դԴԷ

繵ͧѺҴ㹼·դԴԷ

ҧ͹ (CLcr>50-80

./ҷ) лҹҧ (CLcr>35-50 ./ҷ)

·Ѻзҹ::

Ե Թ 5 . Ѻ erythromycin

͹䫴 CYP3A4.



͹

ҹҡеҧ.

ҹä㨷Ңʹʹ

ô Ҩ֧

ҹ ʵ мäѺ ä

Թѹ 1

ҹѺѡä͹öҾҧ



ҡҡüԴ ԴԷҧµ Ǵ

д١ ˹͡

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ѹ

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    / »ա : »ա
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´ҹ

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